The Vampire Facelift is the trademarked name for a non-surgical cosmetic procedure involving the re-injection of a gel-like substance—platelet rich fibrin matrix (PRFM)—derived from a patient’s own blood back into multiple areas of the skin of their face in an effort to treat wrinkles and “rejuvenate” the face.

Platelet-rich plasma (PRP) is blood plasma that has been enriched with platelets. When activated, either by thrombin or calcium chloride, PRP takes on the form of a viscous gel (PRFM) containing high levels of several platelet-derived growth factors (cytokines) that may then be injected into the face in much the same manner as other dermal fillers such as Juvederm and Restylane.

Although any of the many available commercial and non-commercial methods for isolating PRP could theoretically be used to obtain the PRP necessary to perform a Vampire Facelift, most media reports about the procedure to date have described using the Regen Lab system to generate the platelet rich plasma utilized.

As of April 2011, there are no scientific publications that describe the Vampire Facelift procedure or examine its efficacy. There are, however, three publications that report that PRP may be useful as a facial filler.